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Loss of the podocyte-eed transcription factor

Podocytes are terminally differentiated cells with an elaborate cytoskeleton and are critical components of the glomerular barrier. We identified a bHLH transcription factor, Tcf21, that is highly eed in developing and mature podocytes. Because conventional Tcf21 knockout mice die in the perinatal period with major cardiopulmonary defects, we generated a conditional Tcf21 knockout mouse A conditionally immortalized human podocyte cell line Recent molecular insights have established the podocyte as a key component of the glomerular filtration barrier, and hence an important common pathway in proteinuric diseases. A conditionally immortalized human podocyte cell line has been developed by transfection with the temperature-sensitive SV40

Creative Bioarray Launches Human Podocyte Cell Line to

Apr 30, 2021 · Creative Bioarray announced the launch of human podocyte cell line to study the maturation of podocytes in vivo. New York, USA April 30, 2021 Datasets BBrowser - BioTuringThe renal corpuscle of the kidney comprises a glomerular vasculature embraced by podocytes and supported by mesangial myofibroblasts, which ensure plasma filtration at the podocyte-generated slit diaphragm. With a spectrum of podocyte-eed gene mutations causing chronic disease, an enhanced understanding of podocyte development and function to create relevant in vitro podocyte GEO Accession viewerSep 20, 2019 · In vivo developmental trajectories of human podocyte development inform in vitro differentiation of pluripotent stem-cell derived podocytes:Organism:Homo sapiens:Experiment type:Eion profiling by high throughput sequencing:Summary

In Vivo Developmental Trajectories of Human Podocyte

In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes Tracy Tran, Nils O. Lindström, Andrew Ransick, Guilherme De Sena Brandine, Qiuyu Guo, Albert D. Kim, Balint Der, Janos Peti-Peterdi, Andrew D. Smith, Matthew Thornton, Brendan Grubbs, Jill A. McMahon, Andrew P. McMahon * Mapping origins of variation in neural trajectories of Mar 17, 2021 · Variability between human pluripotent stem cell (hPSC) lines remains a challenge and opportunity in biomedicine. We identify differences in the spontaneous self-organization of individual hPSC lines during self-renewal that lie along a fundamental axis of in vivo development. Distinct stable and dynamic transcriptional elements were revealed by decomposition of RNA-seq data in Matthew Thornton - Google ScholarUSC - Cited by 853 - molecular genetics - proteomics - microscopy - developmental biology - stem cell research

Podocyte culture:tricks of the trade. - Abstract - Europe PMC

Aug 01, 2012 · In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes. Tran T, Lindström NO, Ransick A, De Sena Brandine G, Guo Q, Kim AD, Der B, Peti-Peterdi J, Smith AD, Thornton M, Grubbs B, McMahon JA, McMahon AP Dev Cell, 50 (1):102-116.e6, 01 Jul 2019 Podocyte development, disease, and stem cell research Jun 03, 2019 · The glomerular podocyte is one of the major targets of kidney research. Recent establishment of kidney organoids from pluripotent stem cells has enabled the detailed analysis of human podocytes in both development and disease. The podocytes in organoids e slit diaphragmrelated genes and proteins and exhibit characteristic morphology, especially upon Podocyte development, disease, and stem cell researchFeb 28, 2019 · organoids recapitulate the developmental transcription program of the human fetal kidney, and that NPCs diverge into separate trajectories for podocytes and renal tubules, as observed in vivo.15,16,34,35 Gene eion signature characteristics of the developing podocytes, but not differentiated podocytes, correlated with those in diseased

In Vivo Developmental Trajectories of Human Podocyte

In Vivo Developmental Trajectories of Human Podocyte Inform In Vitro Differentiation of Pluripotent Stem Cell-Derived Podocytes Author links open overlay panel Tracy Tran 1 Nils O. Lindström 1 Andrew Ransick 1 Guilherme De Sena Brandine 2 Qiuyu Guo 1 Albert D. Kim 1 Balint Der 3 Janos Peti-Peterdi 3 Andrew D. Smith 2 Matthew Thornton 4 Brendan